Selected publications (2010 to present)
• Dansey, M. V., Palavecino Ruiz, M. D., Ogara, M. F., Pecci, A., Burton, G., Alvarez, L. D. . Insights into estrogen receptor alpha modulation by cholestenoic acids (2022) Journal of Steroid Biochemistry and Molecular Biology. DOI:10.1016/j.jsbmb.2021.106046
• Alvarez, L. D., Dansey, M. V., Ogara, M. F., Peña, C. I., Houtman, R., Veleiro, A. S., Pecci, A., Burton, G. Cholestenoic acid analogues as inverse agonists of the liver X receptors (2020) Journal of Steroid Biochemistry and Molecular Biology. DOI:10.1016/j.jsbmb.2020.105585
• Rodriguez, C. R., Celeste del Fueyo, M., Santillán, V. J., Dansey, M. V., Veleiro, A. S., Castro, O. A., Burton, G. Synthesis and biological activity of fluorinated analogues of the DAF-12 receptor antagonist 24-hydroxy-4-cholen-3-one (2019) Steroids. DOI:10.1016/j.steroids.2019.108469
• Grinman, D. Y., Careaga, V. P., Wellberg, E. A., Dansey, M. V., Kordon, E. C., Anderson, S. M., Maier, M. S., Burton, G., Maclean, P. S., Rudolph, M. C., Pecci, A. Liver X receptor-α activation enhances cholesterol secretion in lactating mammary epithelium. (2019) American Journal of Physiology – Endocrinology and Metabolism. DOI:10.1152/ajpendo.00548.2018
• Martínez, M. D., Ghini, A. A., Dansey, M. V., Veleiro, A. S., Pecci, A., Alvarez, L. D., Burton, G. Synthesis and activity evaluation of a series of cholanamides as modulators of the liver X receptors (2018) Bioorganic and Medicinal Chemistry. DOI:10.1016/j.bmc.2018.01.025
• Stortz, M., Presman, D. M., Bruno, L., Annibale, P., Dansey, M. V., Burton, G., Gratton, E., Pecci, A., Levi, V. Mapping the Dynamics of the Glucocorticoid Receptor within the Nuclear Landscape (2017) Scientific Reports. DOI:10.1038/s41598-017-06676-0
• Rodriguez, C. R., Alvarez, L. D., Dansey, M. V., Paolo, L. S., Veleiro, A. S., Pecci, A., Burton, G. Fluorinated oxysterol analogues: Synthesis, molecular modelling and LXRβ activity (2017) Journal of Steroid Biochemistry and Molecular Biology. DOI:10.1016/j.jsbmb.2016.07.001
• Del Fueyo, M. C., Dansey, M. V., Paolo, L. S., Pecci, A., Veleiro, A. S., Burton, G. C(16)-C(22) oxygen-bridged analogues of ceDAF-12 and LXR ligands (2016) Steroids. DOI:10.1016/j.steroids.2016.05.009
• Pecci, A., Alvarez, L. D., Presman, D. M., Burton, G. 21-hydroxy-6,19-epoxyprogesterone: A promising therapeutic agent and a molecular tool for deciphering glucocorticoid action (2016) Mini-Reviews in Medicinal Chemistry. DOI:10.2174/1389557516666160118112313
• Álvarez, L. D., Dansey, M. V., Grinman, D. Y., Navalesi, D., Samaja, G. A., Del Fueyo, M. C., Bastiaensen, N., Houtman, R., Estrin, D. A., Veleiro, A. S., Pecci, A., Burton, G. Destabilization of the torsioned conformation of a ligand side chain inverts the LXRβ activity (2015) Biochimica et Biophysica Acta – Molecular and Cell Biology of Lipids. DOI:10.1016/j.bbalip.2015.09.007
• Alvarez, L. D., Veleiro, A. S., Burton, G. Exploring the molecular basis of action of ring D aromatic steroidal antiestrogens (2015) Proteins: Structure, Function and Bioinformatics. DOI:10.1002/prot.24820
• Dansey, M. V., Alvarez, L. D., Samaja, G., Escudero, D. S., Veleiro, A. S., Pecci, A., Castro, O. A., Burton, G. Synthetic DAF-12 modulators with potential use in controlling the nematode life cycle (2015) Biochemical Journal. DOI:10.1042/BJ20140833
• Orqueda, A. J., Dansey, M. V., Español, A., Veleiro, A. S., Bal De Kier Joffé, E., Sales, M. E., Burton, G., Pecci, A. The rigid steroid 21-hydroxy-6,19-epoxyprogesterone (21OH-6,19OP) is a dissociated glucocorticoid receptor modulator potentially useful as a novel coadjuvant in breast cancer chemotherapy (2014) Biochemical Pharmacology DOI:10.1016/j.bcp.2014.04.006
• Presman, D. M., Ogara, M. F., Stortz, M., Alvarez, L. D., Pooley, J. R., Schiltz, R. L., Grøntved, L., Johnson, T. A., Mittelstadt, P. R., Ashwell, J. D., Ganesan, S., Burton, G., Levi, V., Hager, G. L., Pecci, A. Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor (2014) PLoS Biology. DOI:10.1371/journal.pbio.1001813
• Samaja, G. A., Castro, O., Alvarez, L. D., Dansey, M. V., Escudero, D. S., Veleiro, A. S., Pecci, A., Burton, G. 27-Nor-Δ4-dafachronic acid is a synthetic ligand of Caenorhabditis elegans DAF-12 receptor (2013) Bioorganic and Medicinal Chemistry Letters. DOI:10.1016/j.bmcl.2013.03.071
• Alvarez, L. D., Mañez, P. A., Estrin, D. A., Burton, G. The Caenorhabditis elegans DAF-12 nuclear receptor: Structure, dynamics, and interaction with ligands (2012) Proteins: Structure, Function and Bioinformatics. DOI:10.1002/prot.24076
• Alvarez, L. D., Dansey, M. V., Martí, M. A., Bertucci, P. Y., Di Chenna, P. H., Pecci, A., Burton, G. Biological activity and ligand binding mode to the progesterone receptor of A-homo analogues of progesterone (2011) Bioorganic and Medicinal Chemistry. DOI:10.1016/j.bmc.2011.01.033
• Presman, D. M., Alvarez, L. D., Levi, V., Eduardo, S., Digman, M. A., Martí, M. A., Veleiro, A. S., Burton, G., Pecci, A. Insights on glucocorticoid receptor activity modulation through the binding of rigid steroids (2010) PLoS ONE. DOI:10.1371/journal.pone.0013279
• Veleiro, A. S., Alvarez, L. D., Eduardo, S. L., Burton, G. Structure of the glucocorticoid receptor, a flexible protein that can adapt to different ligands (2010) ChemMedChem. DOI:10.1002/cmdc.201000014